研究生教学

-基本信息

-研究方向

1. 抗肿瘤药物 针对乳腺癌、白血病等恶性肿瘤的化合物的设计、合成及生物活性研究

2. 细胞器靶向荧光探针研究

-主持课题

1. 抑制白血病细胞生长的萘酰亚胺类化合物的研究。泉州市科技计划项目，项目编号2019C033R

2. 氨萘非特增效、减毒新方法的研究。福建省科技厅社会发展重点项目，项目编号2013Y0066

3. 聚乙二醇修饰的氨萘非特作为抗肿瘤药物的研究。侨办课题，项目编号11J0277

4. 对神经细胞内钙离子和一氧化氮进行同步检测的荧光探针。大连理工大学精细化工国家重点实验室开放课题，项目编号KF0901

5. 含有1，8-萘酰亚胺单体的聚乙烯亚胺类非病毒基因载体的研究。华南肿瘤学国家重点实验室开放课题，2009.8-2011.7

6. 5-位芳香基团取代的萘酰亚胺类化 合物的设计、合成及生物活性研究。项目编号09Y0142

此外参与两项国家自然基金课题研究

-发表文章及专利

1.1 Jinfeng Yu, Hui Bian, Huizi Man, Ning Li, Lijuan Xie,* , Yi Xiao,**Two–photon excitable red fluorophores for imaging living cells. Dyes and Pigments, 2018, 149,851–857

1.2 解丽娟*,陈卓.类呋喃香豆素的合成与DNA的结合及细胞毒性研究.光谱学与光谱分析,2014，34（11），3051-3055 .SCI收录

1.3 解丽娟*，李建民. 7-二乙胺基-3-(2’-吡啶)香豆素的新用途:溶酶体荧光探针.发光学报, 2013, 34(11), 1538-1543.EI收录

1.4 Yinghui Chen, Jianzhang Zhao, Lijuan Xie, Huimin Guo, Qiuting Li. Thienyl-substituted BODIPYs with strong visible light-absorption and long-lived triplet excited states as organic triplet sensitizers for triplet–triplet annihilation upconversion. RSC Adv., 2012, 2, 3942-3953.

1.5 Yinghui Chen, Jianzhang Zhao, Huimin Guo, Lijuan Xie. Geometry Relaxation-Induced Large Stokes Shift in Red-Emitting Borondipyrromethenes (BODIPY) and Applications in Fluorescent Thiol Probes. J. Org. Chem., 2012, 77 (5), 2192–2206.

1.6 Lijuan Xie*, Yinghui Chen, Wenting Wu, Huimin Guo, Jianzhang Zhao, Xuerong Yu. Fluorescent coumarin derivatives with large stokes shift, dual emission and solid state luminescent properties: An experimental and theoretical study. Dyes and Pigments, 2012, 92, 1361-1369.

1.7 Xu Ke; Liang Xin; Wang Fang; Xie Lijuan; Xu Yufang; Liu Jianwen; Qian Xuhong. Induction of G(2)/M phase arrest and apoptosis by potent antitumor APCA in human cervix carcinoma cells. ANTI-CANCER DRUGS., 2011, 22 (9), 875-885.

1.8 Lijuan Xie, Jingnan Cui, Xuhong Qian, Yufang Xu, Jianwen Liu, R.A.Xu. 5-Non-amino aromatic substituted naphthalimides as potential antitumor agents: Synthesis via Suzuki reaction, antiproliferative activity, and DNA-binding behavior. Bioorganic & Medicinal Chemistry, 2011; 19 (2), 961-967.

1.9 Li-juanXie*, 5-Butylamino-2-[2-(dimethylamino)-ethyl]-1H-benz[de] isoquinoline-1,3(2H) -dione. Acta

Crystallographica Section E, 2010, E66, O1454-U1788

1.10 Lijuan Xie,Yi Xiao, Fang Wang, Jianwen Liu, Yufang Xu, Xuhong Qian, Jingnan Cui. Rong Zhang.

Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: Synthesis, cytotoxicity, DNA-binding and cell

cycle evaluation. Bioorganic & Medicinal Chemistry, 2009, 17, 7615–7621.

1.11 Kewei Wang, Jingnan Cui, Lijuan Xie, Xuhong Qian. Design, synthesis, and Evaluation of Unsymmetrical Difluoro-Boron Complexes with Imidazoline as Potential Fungicides. Heteroatom Chemistry, 2009, 20 (7), 418-424.

1.12 Lijuan Xie, Yufang Xu, Fang Wang, Jianwen Liu, Xuhong Qian, Jingnan Cui. Synthesis of new amonafide analogues via coupling reaction and their cytotoxic evaluation and DNA-binding studies. Bioorganic & Medicinal Chemistry, 2009, 16, 804-810.

1.13 Lijuan Xie, Xuhong Qian, Jingnan Cui, Yi Xiao, Kewei Wang, Peichun Wu, Liying Cong. Novel angular furoquinolinones bearing flexible chain as antitumor agent: Design, synthesis, cytotoxic evaluation, and DNA-binding studies. Bioorganic & Medicinal Chemistry, 2008, 16, 8713-8718.

2.12解丽娟(共同专利发明人，第1位)“酰亚胺位或4-位取代的1，8-萘酰亚胺衍生物作为PARP抑制剂的用途”。CN201410072552.3

2.13解丽娟(发明人，第1位)“一类萘酰亚胺双光子荧光染料、其制备方法和应用”。CN201511000130.6

作为共同专利发明人共获得授权专利十三项